Vibrational Coupling as a Probe of Biomolecular Structure and Dynamic

• Applicant: Dr. Tobias Steinel
• Subject Area: Physical Chemistry of Molecules, Liquids and Interfaces, Biophysical Chemistry
• Term: from 2002 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5380625

The proposed project includes experimental and theoretical studies of molecular dynamics as a function of solvent temperature and pressure. Novel twodimensional (2D) vibrational echo experiments, optical analogues to twodimensional NMR-spectroscopy, will be performed on model systems with highly congested vibrational spectra. The 2D-spectra will be analyzed with respect to anharmonicity of the nuclear potential, molecular structure and dynamics. In phase II of the project we intend to apply these techniques also to biochemical systems as a tool for time resolved structure determination. 2D-vibrational echo spectroscopy has the potential to observe the dynamics of the secondary and tertiary structure of proteins and protein-protein interaction.

• DFG Programme: Independent Junior Research Groups