The evolutionary origin of the genetic code (A10)

• Subject Area: Biochemistry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 521256690

The genetic code is a crucial mechanism of life that links a three-letter nucleobase code with the corresponding amino acid, thereby encoding proteins from genetic information. Despite its importance, the evolutionary origin of the genetic code remains poorly understood. We will use a novel sequencing-based high-throughput method to test various theories and proposals about the origin of coded peptide synthesis. Our experiments aim to shed light on whether the genetic code was a random accident or a consequence of molecular reactivities and affinities.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 392: Molecular evolution in prebiotic environments
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Andres Jäschke, since 1/2024