Influence of neuropeptides and catecholamines on endochondral bone formation during fracture healing

• Applicant: Professorin Dr. Susanne Grässel
• Subject Area: Orthopaedics, Traumatology, Reconstructive Surgery
• Term: from 2002 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5354709

• Final Report Year: 2012

Final Report Abstract

No abstract available

Publications

• Altered integration of matrilin –3 into cartilage extracellular matrix in the absence of collagen IX. Mol. Cell Biol. 25 (23): 10465-10478, 2005
  Budde B., Blumbach K., Ylästalo J., Zaucke F., Wagener R., Ehlen HWA, Ala-Kokko L., Paulsson M., Bruckner P., Grässel S.
  
• Collagen IX is indispensable for timely maturation of cartilage during fracture repair in mice. Matrix Biology, 26: 85-95, 2006
  Opolka A., Ratzinger S., Schubert T.E.O., Spiegel H.-U., Grifka J., Bruckner P., Probst A., Grässel S.
  
• Differential distribution pattern of sympathetic nerve fibres and substance P during fracture healing in mice. Osteoarthritis Cartilage 14, Suppl. B: S 52, 2006
  Opolka A, Schubert TEO, Straub RH, Grifka J, Probst A, Grässel S
  
• Collagen IX is indispensable for proper growth plate morphology and organisation. Osteoarthritis Cartilage, Suppl. 15: C99, 2007
  Dreier R, Opolka A, Grifka J, Bruckner P, Grässel S
  
• Collagen IX-deficiency seriously compromises growth cartilage development in mice. Matrix Biol. May; 27(4):319-29, 2008
  Dreier R., Opolka A., Grifka J., Bruckner P., Grässel S.
  
• Genetic mouse models for the functional analysis of the perifibrillar components collagen IX, COMP and matrilin-3: Implications for growth cartilage differentiation and endochondral ossification. J Histo Histopathol. 24: 1067-1079, 2009
  Zaucke F., Grässel S.
  
• Neurotransmitter from the sympathetic and sensory nervous system alter proliferation properties and metabolic activity of chondrocytes in vitro. Osteoarthritis Cartilage, 17, Suppl. 1: S139, 2009
  Grässel S., Opolka A., Straub R. H., Grifka J.
  
• Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis. Arthritis Res Ther. Jun 4;12(3):R110, 2010
  Riepl B., Grässel S., Wiest R., Fleck M., Straub R.H.
  
• Substance P and norepinephrine modulate chondrocyte proliferation and apoptosis. Arthritis & Rheumatism, Oct.31, epub ahead of print, 2011
  Opolka A., Straub R.H., Pasoldt A., Grifka J., Grässel S.