Autophagy mechanisms in intercellular sensing of tissue homeostasis by the immune system (F12*)

• Subject Area: Biochemistry ; Immunology ; Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777

The crosstalk between non-canonical autophagy, maintenance of tissue homeostasis and sensing by the immune system remains poorly understood. This project focuses on secretory autophagy and the regulation of MHC-I-like molecule expression and localization. It will evaluate the impact of mechanisms depending on secretory autophagy and/or regulation of MHC-I-like molecules by autophagy on immune homeostasis in human and murine disease models.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1177: Molecular and Functional Characterization of Selective Autophagy
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Dr. Lina Herhaus; Professor Dr. Andreas Weigert