Molekularer Mechanismus der bakteriellen Membraninsertase YidC

• Antragsteller: Professor Dr. Andreas Kuhn
• Fachliche Zuordnung: Stoffwechselphysiologie, Biochemie und Genetik der Mikroorganismen
• Förderung: Förderung von 2001 bis 2008
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5337410

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2001). Function of YidC for the insertion of M13 procoat protein in E. coli: Translocation of mutants that show differences in their membrane potential dependence and Sec-requirement. J. Biol. Chem. 276, 34847-34852
  Samuelson, J.C, F. Jiang, L. Yi, M. Chen, A. Kuhn and R.E. Dalbey
  
• (2002) Direct interaction of YidC with the Sec-independent Pf3 coat protein during its membrane insertion. J. Biol. Chem. 211, 7610-7615
  Chen, M., J. Samuelson, F. Jiang, M. Müller, A. Kuhn and R. Dalbey
  
• (2003). Defining the regions of the Escherichia coli YidC that contribute to activity. J. Biol Chem. 278, 48965-48972
  Jiang. F., M. Chen, J.-W. de Gier, A. Kuhn and R. Dalbey
  
• (2003). The Alb3/Oxa1/YidC protein family: membrane chaperones facilitating membrane insertion? Trends in Cell Biology 13, 510- 516
  Kuhn, A., R. Stuart, R. Henry and R. Dalbey
  
• (2004). Escherichia coli YidC is a membrane insertase for Sec-independent proteins. EMBO J. 23, 294-301
  Serek, J., G. Bauer-Manz, G. Struhalla, L. Vandenberg, D. Kiefer, R. Dalbey and A. Kuhn
  
• (2004). Membrane integration of E. coli model proteins. Biochim.Biophys.Acta 1694, 55-66
  Facey, S. and A. Kuhn
  
• (2004). YidC family members are involved in the membrane insertion, lateral integration, folding and assembly of membrane proteins. J. Cell Biol. 166, 769-774
  Dalbey, R.E., and A. Kuhn
  
• (2006). Membrane biogenesis of subunit II of cytochrome bo oxidase: Contrasting requirements for insertion of N-terminal and C-terminal domains. J. Mol. Biol. 357, 1428-36
  Celebi, N., L. Yi, S. Facey, A. Kuhn and R. Dalbey
  
• (2005). Involvement of SecDF and YidC in the membrane insertion of M13 procoat mutants. Biochemistry 44, 10741-10749
  Chen, M., J. Yuan, L Yi, K. Xie, S. Facey, N. Pradel, L-F. Wu, A. Kuhn and R. E. Dalbey
  
• (2006). Different regions of the nonconserved large peripiasmic domain of Escherichia coli YidC are involved in SecF Interaction and in membrane insertase activity. Biochemistry 45,13401-13408
  Xie, K., D. Kiefer, G. Nagler, R. Dalbey, and A. Kuhn
  
• (2007). The mechanosensitive Channel protein MscL is targeted by SRP to the novel YidC membrane insertion pathway of E. coli. J. Mol. Biol. 385, 995-1004
  Facey, S., S. Neugebauer, S. Krauss and A. Kuhn
  
• (2007). YidC is an essential and multifunctional component in membrane protein assembly. Int Cytolog. Rev.259, 113-138
  Kiefer, D. and A. Kuhn
  
• (2008). Initial binding process of the membrane insertase YidC with its substrate protein Pf3 coat. Biochemistry 47, 6052-6058
  Gerken, U., D. Erhardt, A. Schubert, G. Bär, R. Ghosh, and A. Kuhn
  
• (2008). The Pf3 coat protein contacts TMI and TM3 of YidC during membrane biogenesis. FEBS letters 582, 3967-3972
  Klenner, C., J. Yuan, R. Dalbey and A. Kuhn
  
• (2009). From the Sec complex to the membrane insertase YidC. Biol. Chem.
  Kuhn, A.
  
• (2009). Substrateinduced conformational change of the E. coli membrane insertase YidC. Biochemistry
  Winterfeld, S., N. Imhof, T. Roos, G. Bär, A. Kuhn and U. Gerken