Molekulare Analyse von Zytokingenpromotoren und TH2-Zytokinsignaltransduktion bei asthmatischen Entzündungsreaktionen

• Applicant: Professorin Susetta Finotto, Ph.D.
• Subject Area: Gastroenterology
• Term: from 2001 to 2007
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5302678

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• 2004. A stage-specific functional role of the leucine zipper transcription factor c- Maf in lung Th2 cell differentiation . Eur J Immunol. 34 (12):3401-12
  Hausding M., I.C.Ho, H.A. Lehr, B. Weigmann , C. Lux, M. Schipp, P.R. Galle, and S. Finotto
  
• Asthmatic changes in mice lacking T-bet are mediated by IL-13. Int Immunol.2005.17(81:993-1007
  Finotto S, Hausding M, Doganci A, Maxeiner JH, Lehr HA, Luft C, Galle PR, Glimcher LH
  
• Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science.2002.295:336
  Finotto S., Neurath MF, Glickman JN, Qin S, Lehr HA, Green FHY, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, DeSanctis GT, and Glimcher LH
  
• Local administration of antisense phosphorothioate oligonucleotides to the c-kit ligand, stem cell factor, suppresses airway inflammation and IL-4 production in a murine model of asthma. J Allergy Clin Immunol 2001.107(2):279-86
  Finotto S, Buerke M, Lingnau K, Schmitt E, Galle PR, Neurath MF
  
• The IL-6R chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J. Clin. Invest. 2005. 115:313-325
  A. Doganci, T. Eigenbrod, N. Krug, G. T. De Sanctis, M. Hausding, V. J. Erpenbeck, E-B. Haddad, E. Schmitt, T. Bopp, K.-J. Kallen, U. Herz, S. Schmitt, C. Luft, O. Hecht, J. M. Hohlfeld, H, Ito, N. Nishimoto, K. Yoshizaki, T. Kishimoto, S. Rose-John, H. Renz, M. F. Neurath, P. R. Galle and Finotto S.
  
• Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression. J Exp Med. 2001.4;193(11):1247-60
  Finotto S. DeSanctis, Lehr H.A., Herz U., Buerke M., Schipp M, Barsch B, Atreya R Schmitt E, Galle PR, Renz H, Neurath MF
  
• Isolation of CD4(+) T cells from murine lungs: a method to analyze ongoing immune responses in the lung. Nat Protoc. 2006; l(6):2870-5
  Sauer KA, Scholtes P, Karwot R, Finotto S
  
• A method to enable the investigation of murine bronchial immune cells, their cytokines and mediators.Nat Protoc. 2007;2(1):105-12
  Maxeiner JH, Karwot R, Hausding M, Sauer KA, Scholtes P, Finotto S
  
• Local blockade of IL- 6R signaling induces lung T cell apoptosis in asthma via regulatory T cells. Int Immunol. 2007.19(6):685-93
  S. Finotto. T. Eigenbrod, R. Karwot, I. Boross, A. Doganci, H. Ito, N. Nishimoto, K. Yoshizaki, T. Kishimoto, S. Rose-John, P. R. Galle, and M. F. Neurath
  
• Lung CDllc+ cells deficient in Epstein-Barr virus induced gene 3 (EBI-3)prevent airway hyperresponsiveness in experimental asthma. Eur. J. of Immunol. 2007.37(6): 1663-77
  M. Hausding, R. Karwot, P. Scholtes, J. Maxeiner, K. Sauer, H. A. Lehr, A. Doganci, M. Wegmann0, H. Renz, P. R. Galle, M. Birkenbach,M. F. Neurath, MD, R.S. Blumberg, and S, Finotto