Differentiation and fate of osteoclasts during health and disease (C04)

• Subject Area: Rheumatology ; Immunology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319

Project C04 will address the concept that osteoclasts during inflammation could stem from bone marrow-derived cells, while resident embryonic precursors give rise to osteoclasts under steady state conditions. A major question that should be addressed in this project is whether these different osteoclast sub-populations display not only different origins, but also divergent activation profiles and functions. Such insights into osteoclast heterogeneity might provide a better understanding of osteoclast-related pathologies during inflammatory diseases as well as new targets for more specific therapeutic interventions during diseases such as RA and periodontitis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 369: DIONE Degeneration of bone induced by inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Professorin Dr. Anika Grüneboom; Professor Dr. Gerhard Krönke