Cross talk between skin and joints impairs bone homeostasis in psoriatic arthritis (A04)

• Subject Area: Immunology ; Dermatology ; Pediatric and Adolescent Medicine ; Clinical Immunology and Allergology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319

Project A04 aims to define molecular pathways that trigger disease spreading from the skin to the bone to develop new ways to target inflammatory bone remodeling in these patients. Project A04 will identify molecular culprits in the skin that allow spread of inflammation and study the functional effects of transmigrating cells within the bone niche. The project will explain how inflammatory skin diseases such as psoriasis trigger bone loss.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 369: DIONE Degeneration of bone induced by inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Professorin Dr. Claudia Günther; Professor Dr. Andreas Ramming