The influence of interneurons’ active dendritic properties on neuronal information encoding in the neocortex (B08)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514483642

The encoding of information in the cortical microcircuit is shaped by a wide range of GABAergic inhibitory interneurons (INs). However, the role of IN dendrites in the encoding process is poorly understood. Our preliminary data reveal that dendrites of neocortical INs are enriched by regenerative activity such as the NMDA-dependent local spikes. Using direct dendritic recordings, we will study the dendritic properties of the different INs types. We will characterize the functional connectivity within the cortical network with state-of-the-art circuit-mapping techniques. Using simulation tools, we will model single INs and small networks to reveal how the population code is controlled by INs sub-circuits.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 384: Inhibitory neurons: shaping the cortical code (IN-CODE)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Matthew Larkum