Role of dentate gyrus GABAergic interneuron types in long-term information encoding by principal cells (A01)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514483642

Here we aim to examine how interneuron (IN) types contribute to high spatial map stability in the mouse dentate gyrus (DG). To address this question, we will perform 2- / 3-photon calcium imaging of neuron populations in head-fixed mice navigating through virtual realities. We will apply pharmaco-/optogenetic tools to modulate IN type activity to examine its influence on population activity and behavior. By performing deca-patch recordings in acute slices, we will examine the underlying structural-functional microcircuit organization. By using artificial intelligence algorithms, we will uncover how INs contribute to internal structure of active networks & encoding of behavioral variables at the level of population codes.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 384: Inhibitory neurons: shaping the cortical code (IN-CODE)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Marlene Bartos