Decisive factors to induce cell death via oxeiptosis and the relationship to other forms of regulated cell death (B04)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 471011418

Reactive oxygen species (ROS) can affect and drive cell death decisions for a number of modalities, including apoptosis, necroptosis and ferroptosis. This project will investigate the decisions between a novel form of ROS-regulated cell death, termed oxeiptosis, and other cell death modalities. Specifically, it will address how oxidation of the sensory protein KEAP1 differentially regulates the activation of downstream effectors, and subsequently the decision of cell death induction by oxeiptosis, apoptosis, necroptosis and ferroptosis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 353: Regulation of cell death decisions
• Applicant Institution: Universität Konstanz
• Project Head: Professor Dr. Andreas Pichlmair