The role of SPATA2 for the decision between cell death and survival (B03)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 471011418

Post-translational regulation of signaling complexes by ubiquitylation and deubiquitylation critically contributes to the outcome of death receptor activation. This project will investigate how the protein SPATA2 regulates cell death decision-making processes by recruiting the deubiquitinase CYLD to the TNF receptor 1 complex, but also CYLD-independently. It will further determine how post-translational modifications of SPATA2 define a balance between TNF-induced survival, apoptosis, necroptosis and pyroptosis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 353: Regulation of cell death decisions
• Applicant Institution: Universität Konstanz
• Project Head: Privatdozent Dr. Ulrich Maurer