The role of RIP kinase 1 in the decision of apoptosis and pyroptosis induction during intracellular bacterial infection (B02)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 471011418

Salmonella Typhimurium (STy) is a facultative intracellular bacterium that infects both myeloid cells and intestinal epithelial cells. This project will investigate how RIPK1 regulates cell death processes in STy-infected myeloid or intestinal epithelial cells, and how the RIPK1-dependent decision is made whether infected target cells die by apoptosis, or by lytic cell death, such as pyroptosis or necroptosis. It will particularly address the role of RIPK1 kinase activity versus scaffold function in these death decision-making processes.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 353: Regulation of cell death decisions
• Applicant Institution: Universität Konstanz
• Project Head: Dr. Gregor Ebert