Determinants of mitochondrial cell death in virus-infected hepatocytes (A03)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 471011418

Hepatocytes are type II cells, in which death receptor-induced apoptosis depends on the amplification of the signal by mitochondria. Interestingly, virally infected hepatocytes show increased susceptibility to TNF-induced apoptosis. This project will investigate how increased protein synthesis in virus-infected cells alters the mitochondrial metabolism and thereby resilience to TNF-induced hepatocyte apoptosis. Finally, the project will study why hepatitis B virus does not induce apoptosis and fails to reduce mitochondrial resilience.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 353: Regulation of cell death decisions
• Applicant Institution: Universität Konstanz
• Project Head: Privatdozent Dr. Dirk Wohlleber