Microbial regulation of cell death induction in the intestinal tract (A02)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 471011418

TNF is a cytokine readily expressed and released under most inflammatory conditions. Intestinal epithelial cells are among the few cell types directly sensitive to TNF-induced cell death. This project will investigate how TNF-induced intestinal epithelial cell death is regulated by metabolites derived from the intestinal microbiome. It will further analyze how caspase 8-mediated cleavage of Gasdermins and associated pyroptosis contributes to TNF-induced cell death in intestinal stem cells versus mature epithelial cells.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 353: Regulation of cell death decisions
• Applicant Institution: Universität Konstanz
• Project Head: Dr. Monica Yabal