Action of Probiotic Lactic Acid Bacteria on Skin Pathogens in an Ex-vivo Skin Model

• Applicants: Dr. Marc Burian; Dr. Elisabeth Heine
• Subject Area: Dermatology ; Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 526032942

In this project, the antimicrobial action of probiotic bacteria (a strain of Lactiplantibacillus plantarum) on native or infected human ex-vivo skin shall be investigated. The primary goal is to develop this probiotic (enclosed in suitable membranes) for "antibiotic-free" treatment of bacteria-associated skin diseases. The L. plantarum strain chosen shall be optimized concerning its bacteriocin production and tested for the action of its mutants in the ex-vivo skin model.

• DFG Programme: Research Grants
• Co-Investigator: Professor Dr. Rudolf Lütticken