The impact of nitrated fatty acids in a translational porcine model of abdominal aortic aneurysm (C03*)

• Subject Area: Cardiology, Angiology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 397484323

We will establish and characterise a large animal model of abdominal aortic aneurysm disease (AAA) in pigs by aortic porcine pancreatic elastase (PPE) infusion. In a therapeutic approach, we will investigate the role of the anti-inflammatory nitro-oleic acid (NO2-OA) in a PPE mouse model and translate obtained results into the porcine AAA model. Furthermore, we will establish an infrastructure for large animal experiments, which will allow the utilisation of a standardised porcine model of AAA disease by the whole consortium, including adjustments to specific project requirements, animal transportation and ethics preparation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 259: Aortic Disease
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Martin Mollenhauer, Ph.D., since 7/2023; Dr. Marta Stei, since 7/2023; Dr. Markus Wagenhäuser, since 7/2023