A reverse genetic approach to define physiologically important functional domains of APP family proteins: analysis in APP/APLP knockout mice

• Applicant: Professorin Dr. Ulrike Müller
• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2000 to 2007
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5247598

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• (2004). Cortical Dysplasia Resembling Human Type 2 Lissencephaly in Mice Lacking all Three APP-Family Members. The EMBO J. 23: 4106 - 4115
  Herms, J., Anliker, B., Heber, S., Ring, S., Fuhrmann, M., Kretzschmar, H., Sisodia, S. and Müller, U.
  
• (2005) Homo- and hetero-dimerization of APP family members promotes intercellular adhesion. EMBO J. 24: 3624-3634
  Soba, P. , Eggert, S., Zentgraf, H., Siehl, K., Kreger, S., Löwer, A., Langer, A., Merdes, G., Paro, R., Masters, C. L., Müller, U., Kins, S. and Konrad Beyreuther
  
• (2005). Lengthening of G2/mitosis in cortical precursors from mice lacking ß-amyloid precursor protein. Neuroscience 130:51-60
  Lopez-Sanchez, M., Müller, U. and Frade, J. M.
  
• (2005). Regulation of cholesterol and sphingomyelin metabolism by amyloid-ß and presenilin. Nat. Cell. Biol. 7: 1118-1123
  Grimm, M. O. W., Grimm, H. S., Pätzold, A. J., Zinser, E. G., Halonen, R., Duering, M., Tschäpe, J.-A., De Strooper, B., Müller, U., Shen, J. and Hartmann, T.
  
• (2005). Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases. FEBS J. 272: 5808-5820
  Endres, K., Postina, R., Schröder, A., Müller, U. and Fahrenholz, F.
  
• (2007) Beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment. J Neurosci Res. 85: 2580-2590
  Back S, Haas P, Tschape JA, Gruebl T, Kirsch J, Müller U, Beyreuther K, and Kins S
  
• (2007) The secreted APPsα domain is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP deficient mice. J. Neuroscience 27: 7817-7826
  Ring. S, Weyer, S., Kilian, S. B., Waldron, E., Pietrzik, C. U., Filippov, M., Herms, J., Buchholz, C., Eckman, C. B., Martin Korte, M., Wolfer, D. P. and Müller, U.