FOR 5705:  NeuroFlame – Defence and demise of inflamed neurons

• Subject Area: Medicine
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 523862973

Neuroinflammation has emerged as a central unifying theme in a wide range of neurological pathologies. Besides diseases with obvious inflammatory character, like multiple sclerosis, also the course of neurodegenerative, vascular, and traumatic brain diseases proves to be heavily influenced by neuroinflammation. However, despite the urgent need for neuroprotective treatments in all of these conditions, a detailed understanding of how neuroinflammation affects neuronal function and viability is lacking. The mission of NeuroFlame Research Unit is to close this gap in knowledge by gathering thought leaders and methodological experts in the field to explore neuronal defence strategies and injurious pathways, establish causal relationships by experimental interference and work out the sequence of events that determines neuronal outcome in the face of neuroinflammation. This collaborative effort will lay the foundation for the development of new neuroprotective treatments with broad applicability.

• DFG Programme: Research Units
• International Connection: Sweden

Projects

• Axonal transport and presynaptic function during neuroinflammation (Applicants Kneussel, Ph.D., Matthias ;  Lipstein-Thoms, Ph.D., Noa )
• Coordination Funds (Applicant Friese, Manuel A. )
• Decoding vulnerability of sensorimotor neurons to neuroinflammation (Applicants Kuner, Thomas ;  Schirmer, Lucas )
• Epigenetic control of neurogenesis and neuronal loss in neuroinflammation (Applicants Engler, Jan Broder ;  Rosenkranz, Sina Cathérine )
• Genetic determinants of neurodegeneration during CNS inflammation (Applicants Jagodic, Maja ;  Stridh, Ph.D., Pernilla )
• Neuronal control of phagocytes during CNS inflammation (Applicants Bareyre, Ph.D., Florence ;  Kerschensteiner, Martin )
• Neuronal NAADP signalling during neuroinflammation (Applicants Freichel, Marc ;  Guse, Andreas H. )
• Neuronal proteostasis during neuroinflammation (Applicants Friese, Manuel A. ;  Meyer-Schwesinger, Catherine )
• PRR7 as synaptic gatekeeper during neuroinflammation (Applicants Kreutz, Michael R. ;  Mikhaylova, Marina )
• PZ1 | Translational neuropathology and novel tissue methods platform (Applicants Glatzel, Markus ;  Stadelmann-Nessler, Christine )

• Spokesperson: Professor Dr. Manuel A. Friese