500 MHz-NMR-Spectrometer

• Subject Area: Molecular Chemistry
• Term: Funded in 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 522001443

Research at the Faculty of Chemistry and Food Chemistry at TU Dresden deals intensively with the synthesis and analysis of molecules within the fields of bioorganic chemistry, food chemistry, organometallic chemistry, inorganic molecular chemistry and materials chemistry. In addition, the structural elucidation of complex natural products from biomolecular natural product research in Technical Biochemistry plays an increasingly important role. The overall resulting measurement time requirements in routine analysis, which has increased significantly in recent years, as well as for more complex, time-consuming 2D NMR experiments, can no longer be met with the NMR equipment currently available. A modern 500 MHz NMR spectrometer with broadband BBFO probe head (5 mm) is therefore requested, which allows efficient routine measurement with high 13C and simultaneously high 1H sensitivity and also opens up the urgently needed possibility for measurements in routine 2D experiments on samples with normal concentration (> 5 mg/mL), thus significantly relieving the existing 600 MHz system. In addition, the system is supplemented with a 3 mm BBI probe head with high 1H sensitivity, which enables measurement in much smaller sample volumes and thus also allows work with substances in the sub-mg range. Efficient use of the device is ensured by installing an autosampler. The device should have an automatic tuning and matching unit to adjust the probe head to the samples to be examined. This is the only way to facilitate real automatic measurements in the autosampler mode. In addition to the significant increase in sensitivity, which is accompanied by a saving in measurement time, modern shim methods can be used with this device. This increases the resolution of the device, i.e. the measurement quality. The system will be integrated into the newly founded technology platform T-CHE (technology platform "Chemical Analysis") of the faculty and will thereby be made available to a large number of other users of the TU Dresden beyond the listed main users. In automatic routine NMR operation, it is to be used to carry out 1D and 2D experiments on samples with normal conentrations. It is therefore of essential importance for the research performance of the Faculty of Chemistry and Food Chemistry, the other users of the TU Dresden and the entire Dresden Science Area.

• DFG Programme: Major Research Instrumentation
• Major Instrumentation: 500 MHz-NMR-Spektrometer
• Instrumentation Group: 1740 Hochauflösende NMR-Spektrometer
• Applicant Institution: Technische Universität Dresden
• Leader: Professor Dr. Tobias A. M. Gulder