Charakterisierung und Optimierung eines Ultraschall Zellrückhaltesystems, Erstellung eines mechanistischen Modells zur Beschreibung der räumlichen Vorgänge, Ausweitung des Modells auf CHO-Zellen und Exp. Überprüfung des Modells anhand verschiedener Kultivierungen, Übertragung des Prinzips in einen größeren Maßstab

• Applicant: Dr. Volker Gorenflo
• Subject Area: Biological Process Engineering
• Term: from 1999 to 2005
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5205174

Mammalian cell culture biochemical engineering has been critical to the development of bioreactor and bioprocess technology for recombinant protein production. More recently, there has been rapidly increasing interest in cell culture for medical tissue engineering, cellular therapy and gene therapy. Research in the group of Prof. J. M. Piret is targeted at optimizing the design and operation of stirred suspension and high cell density processes. By increasing the fundamental understanding of these bioreactor devices, the proposed research should accelerate their development and optimizion both for recombinant protein production and for the emerging medical cell culture applications. This research should provide a high qualitiy multidisciplinary training environment in biochemical engineering and applied biological sciences.

• DFG Programme: Research Fellowships