Neural implant technology for epicortical, multimodal modulation of craving behaviour in addiction

• Applicant: Privatdozentin Nadine Bernhardt, Ph.D.
• Subject Area: Biomedical Systems Technology ; Experimental Models for the Understanding of Nervous System Diseases ; Microsystems
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 518530049

A substance use disorder development is associated with an excessive and persistent urge for a drug and out-of-control consumption behaviour. Such cognitive impairments and altered behaviour control can be linked to deficits in neurophysiological activity and neurotransmitter metabolism. Addictive disorders arise from a complex interplay of genetic, social and environmental factors making treatment challenging. Relapse rates remain high. Multimodal neuroprosthetics, equipped with multiple sensing and stimulation abilities, enable measurement and targeted modulation of impaired neural function. In addition, the implementation of soft and biocompatible implant materials allows long-term application at low risk. In the proposed project, we develop a biomedical device to measure disease-induced alterations of neuronal activity that will be normalised through implant-driven electrical and pharmacological stimulation to prevent relapse. In a minimally invasive surgical intervention, we implant the neuroprosthesis directly on the brain surface in a rat model of alcohol addiction. The acquired data will be analysed using custom machine learning algorithms aiming to autonomously identify disease-related brain states and switch on stimulation only when necessary, enabling individualised and optimised therapy.

• DFG Programme: Research Grants
• International Connection: United Kingdom
• Co-Investigator: Professor Dr. Rainer Spanagel
• Cooperation Partners: Mahnaz Arvaneh, Ph.D.; Professor Ivan Minev, Ph.D.