Regulation and Role of Physical Properties for Transcriptional Condensates (R12)

• Subject Area: Experimental and Theoretical Physics of Polymers
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464588647

Several important transcriptional regulators reside in membraneless condensates that ensure stable transcription of cell identity genes. The underlying physical and biological forces and dependencies regulating these transcriptional condensates in vivo are hardly understood. In this project, we aim to develop a comprehensive understanding of transcriptional condensates and the interdependencies of their constituents by combining systematic imaging of their components in cells after perturbations with physics-based multi-scale modelling.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1551: Polymer Concepts in Cellular Function
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Dr. Sandra Schick-Nickolaus; Professor Dr. Thomas Speck