Project Details
Projekt
A Supramolecular Chemical Biology Approach to Studying Protein–RNA-Based Regulatory Switches (R05)
Subject Area
Experimental and Theoretical Physics of Polymers
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 464588647
We will investigate mechanisms of switch-like all-or-none responses in biological systems from the point of view of physical-chemistry and polymer science. Our model system is a biological switch with relevance in neurodegenerative diseases: The regulation of RNA splicing by the RNA-binding protein HNRNPH. We will investigate the biophysical determinants in this process by an interdisciplinary effort combining functional genomics (biology), the synthesis and characterisation of artificial biomimetic polymer assembly platforms (supramolecular chemistry), and theoretical modelling (physics).
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1551:
Polymer Concepts in Cellular Function
Applicant Institution
Johannes Gutenberg-Universität Mainz
