Project Details
Projekt
Functions of Ubiquitin and SUMO in Protein Phase Separation and Aggregation (R02)
Subject Area
Biochemistry
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 464588647
The project focuses on a systematic investigation of the effects of ubiquitylation and SUMOylation on the propensity of proteins to undergo phase separation and aggregation. To this end, we combine biochemical and biophysical approaches with multiscale molecular simulations. Based on a set of model ubiquitylation and/or SUMOylation target proteins relevant to neurodegenerative diseases, we will perform in vitro and in silico studies to understand and be able to predict the molecular interactions that govern phase separation and aggregation and explain the properties of the resulting condensates and aggregates.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1551:
Polymer Concepts in Cellular Function
Applicant Institution
Johannes Gutenberg-Universität Mainz
