C-H bond activation in Ribonucleotide reductases

• Applicant: Professor Dr. Hendrik Zipse
• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 1999 to 2006
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5176960

The C-H bond activation process in ribonucleotide reductases will be studied using state of the art ab initio methods. The enzyme will be described as a set of free floating or partially restricted amino acid side chains interacting with model substrates. Once an arrangement and a selection of side chains has been found, which is in line with experimental observation, this array of functional groups can be used to study the chemistry of known reductase inhibitors and aid the design of new compounds with inhibitory activity.

• DFG Programme: Priority Programmes
• Subproject of: SPP 1071: Radikale in der enzymatischen Katalyse