Microbiota-induced intestinal Treg cells modulate neuroinflammation (B04)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 490846870

We have previously shown that intestinal Treg cells can be enriched through manipulation of the gut microbiota composition, consequently ameliorating neuroinflammation after ischemic stroke and during EAE. Now, we aim to identify the specific microbiota metabolites that can induce these CNS protecting intestinal Treg cells, in both mouse and man, and how neuroinflammation itself can induce changes in the gut microbiota composition, potentially affecting Treg cell identity and function. The precise understanding of these intestinal Treg cells relevant for neuroinflammation should enable the therapeutic exploitation of the microbiota to provoke Treg cell responses dampening neuroinflammation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 355: Heterogeneity and functional specialization of regulatory T cells in distinct microenvironments
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Dr. Corinne Benakis; Dr. Tommy Regen