In silico modelling of mechanical cell-matrix interactions (C01)

• Subject Area: Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics ; Mechanics
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 460333672

C01 combines modelling and simulation to uncover the role of mechanical cell-matrix interactions in brain tissue. Agent-based and coarse grained/phenomenological continuum models will account for cell-matrix interactions, cell migration and active force generation. Via in silico implementations, we will predict how cell-cell and cell-matrix interactions define the mechanical properties of the system at the continuum level. We will furthermore study the dynamics of neuronal organoid formation in artificial matrices based on nonlinear continuum modelling and simulation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1540: Exploring Brain Mechanics (EBM): Understanding, engineering and exploiting mechanical properties and signals in central nervous system development, physiology and pathology
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Professor Dr.-Ing. Paul Steinmann; Professor Vasily Zaburdaev, Ph.D.