Plasticity and adaptation of the endosomal system (P14)

• Subject Area: Cell Biology ; Biochemistry
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project will focus on the role of the nutrient and stress regulated peripheral membrane protein complexes, the Fab1/PIKfyve lipid kinase (FAB1C) and the target of rapamycin complex 1 (TORC1), on signaling endosomes (SE). This project will address the functional plasticity of SE membrane composition and thus organelle biogenesis, determine how FAB1C and TORC1 signaling affects SE function, and how these complexes control the fusion and fission machinery the identity of SEs and the endolysosomal system in general.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Professor Dr. Christian Ungermann