Plasticity and adaptation of the endocytic membrane compartment in nephrocyte differentiation (P12)

• Subject Area: Cell Biology ; Developmental Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project will focus on labyrinth channels at the plasma membrane of nephrocytes, about 100 µm large kidney-like cells in Drosophila. These channels are dynamic filtration units with strong endocytic activity. How these structures are formed by membrane proteins and how they are linked to the endolysosomal system remains incompletely understood. The project will address the biology of these structures by focusing on the role of membrane proteins at the channels and their link to the endolysosomal system and the actin cytoskeleton.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Professor Dr. Achim Paululat