Adaptation of a Rab/GEF module for initiation and maintenance of planar cell polarity and cilia (P10)

• Subject Area: Biochemistry ; Structural Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project will concentrate on the regulation of organelle identity in vesicular trafficking, where a guanine nucleotide exchange factor (GEF) complex involved in planar cell polarity, termed Fuzzy-Inturned, activates the Rab23 GTPase. The project will focus on how structure and function of Fuzzy-Inturned is regulated by interactions with the plasma membrane and the cytoskeleton.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Professor Dr. Daniel Kümmel