Plasticity and biological relevance of organellar lipid codes (P09)

• Subject Area: Cell Biology ; Biochemistry
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project will focus on the functional consequences of and compensatory cellular responses to imbalances in organellar lipid codes caused by pathogenic variants of the sphingomyelin synthase SMS2. How mislocalization of this enzyme affects membrane lipid homeostasis in relation to extracellular vesicle formation by osteogenic cells and the implications in dysregulated bone formation will be addressed in detail.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Professor Dr. Joost Holthuis