Plasticity of the serine palmitoyl transferase complex during adaption of sphingolipid metabolism (P06)

• Subject Area: Biochemistry ; Structural Biology ; Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project will focus on a key enzyme in sphingolipid biogenesis, the rate-limiting serine palmitoyltransferase (SPT) enzyme complex. The function of this complex and its regulation by three accessory proteins will be analyzed under different cellular conditions to understand how metabolic sphingolipid fluxes are controlled at the molecular level and to explore their physiological relevance.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Professor Dr. Florian Fröhlich