Plasticity of GSDM pores for the control of pyroptotic cell death (P05)

• Subject Area: Cell Biology ; Biophysics
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project will analyze the regulatory mechanisms by which pore formation by Gasdermins at the plasma membrane results in pyroptosis, an inflammatory form of regulated cell death. The project will unravel how membrane properties regulate Gasdermin recruitment to subcellular membranes and pore formation, and how the protein activity is altered by membrane modulators, thus clarifying the functional plasticity of Gasdermin pore formation in pyroptosis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Professorin Dr. Katia Cosentino