Remodelling and exploitation of the host lipid trafficking machinery by pathogenic mycobacteria (P01)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project will exploit Dictyostelium infected with mycobacteria that are proficient or defective in the secretion of bacterial effectors. The goal is to investigate how these pathogens reprogram metabolic lipid flows and consequently impact on the functional plasticity of the mycobacteria-containing vacuole (MCV) membrane composition. This includes a systematic search for novel components of the host lipid trafficking machinery, their effects on MCV function and their role in mycobacterial intracellular growth.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Dr. Caroline Barisch