Impact of neonatal CMV infection on lung macrophage development (A02)

• Subject Area: Immunology ; Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693

P. Henneke and Z. Ruzsics recently discovered that cytomegalovirus (CMV) remodels the identity of fully differentiated alveolar macrophages (Mφ). A02 combines this knowledge with insights into how chronic infections manipulate Mφ progenitors to explore how perinatal CMV infections impact on innate cellular barrier immunity. A particular focus will be renewal and function of resident lung Mφ subsets, and thus on immunity to bacterial pneumonia later in life. Several groups in the consortium will profit from the broad expertise in viral and bacterial neonatal infections, and myeloid cell development as provided by A02.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 359: Perinatal Development of Immune Cell Topology
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Philipp Henneke; Dr. Zsolt Ruzsics