Metabolic control of innate and adaptive immune responses to cutaneous Staphylococcus aureus infection (C02)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 492620490

C02 will investigate how the metabolic competition between immune cells of the host and Staphyloccocus aureus shapes local immunity and how glucose uptake mechanisms of innate and adaptive immune cells prevent the spreading of the pathogen to secondary infection sites. C02 hypothesises that the metabolic and epigenetic reprogramming of T cells and neutrophils is relevant for determining local immunity and systemic protection from S. aureus infections and aim to characterise decision points governing this reprogramming.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1583: Decisions in Infectious Diseases (DECIDE)
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Head: Martin Väth, Ph.D.