Dissecting the structural and functional crosstalk of the protein synthesis and ISG15-modification machineries (P17)

• Subject Area: Structural Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 469281184

Posttranslational modifications with ubiquitin and ubiquitin-like modifiers (Ubls) are pivotal regulators of diverse aspects of gene expression. This project focuses on the interplay of the 80S ribosome with components of the Ubl modification machinery, including cryo-EM analyses of catalytic complexes at the ribosome, in-vitro studies of the mechanism and selectivity of ribosome-associated modifications, and the cell-based identification of the pre-requisites thereof.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1565: Molecular mechanisms and interplay of gene expression processes
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Dr. Sonja Gisela Lorenz