Coordination of genome maintenance and gene expression processes through multifunctional molecular machineries (P05)

• Subject Area: Structural Biology ; Biochemistry
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 469281184

Human activating signal co-integrator complex (ASCC) is involved in numerous genome maintenance, gene expression and gene regulation processes, representing a paradigmatic example for the coupling between such processes via multi-functional molecular machinery (moonlighting). Employing a combined biochemical, structural and multi-omics approach, this project will investigate how ASCC is embedded into, and exerts functions within, diverse molecular contexts, thereby contributing to central themes of this CRC on the mechanisms and coordination of gene regulatory machineries.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1565: Molecular mechanisms and interplay of gene expression processes
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Markus C. Wahl