Unraveling molecular circuits leading to catecholamine-driven ventricular arrhythmias (B09)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464424253

We identified OCaR2 as a regulator of lysosomal two-pore channels, and its deletion resulted in Ca2+ oscillations in cardiomyocytes causing fatal catecholaminergic arrhythmias. We combine Ca2+ imaging, ECG telemetry, transcriptome and metabolome approaches with computational methods to elucidate pathways and patterns of gene regulation. By comparative analysis of circuits in arrhythmogenic cardiomyopathy models, we aim to determine common molecular circuits in the pathogenesis of catecholamine driven ventricular arrhythmias.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1550: Molecular Circuits of Heart Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Marc Freichel; Rebecca Levinson, Ph.D.