Cardiocrine signaling as a regulator of cardiac homeostasis and fibrosis (B06)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464424253

Cardiomyocytes communicate with their surrounding cells through mechanical and chemical interactions. A novel mass spectrometry based approach enabled us to characterize the secretome of primary cardiomyocytes. For this proposal, we will investigate down-stream paracrine and autocrine effects of the identified, most strongly regulated signal proteins under hypoxia. In addition, we will determine their upstream regulation in cardiomyocytes to elucidate the circuit of cardiocrine signaling during homeostasis and stress.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1550: Molecular Circuits of Heart Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Florian Leuschner