Inflammation begets inflammation – impact of remote injuries on atherosclerosis progression (B11*)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 238187445

We identified in our collaborative preliminary work that sterile injuries such as ischemic stroke (IS) and myocardial infarction (MI) lead to the destabilization of vulnerable atherosclerotic plaques and recurrent ischemic events. However, the exact mechanisms underlying secondary plaque rupture after remote organ injury and the comparability of the involved mechanisms between different sterile injuries are unknown. In this project we will perform a deep characterization of the systemic inflammatory response in experimental models of IS and MI and human patient material to identify specific key pathways as causative and druggable targets involved in plaque destabilization after remote injuries.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1123: Atherosclerosis: Mechanisms and Networks of Novel Therapeutic Targets
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Arthur Liesz; Professor Dr. Hendrik Sager