The role of Ly6g and CD177 as “eat me” signals to control neutrophil-mediated tissue destruction in stroke (C06)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

Among murine leukocytes neutrophils exclusively express high levels of Ly6G. The human analogue, CD177, is lacking on neutrophils in ~5% of the general population. However, the functional role of both molecules remains unknown. In this project, we will investigate the hypothesis that Ly6G/CD177mediates the phagocytosis of brain-infiltrating neutrophils through microglia. By elucidating the underlying mechanisms, we aim to identify means for its selective therapeutic modulation in stroke. In a clinical setting we will investigate the importance of CD177 for the outcome and future clinical management of human stroke.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Matthias Gunzer, since 7/2022; Professor Dr. Dirk M. Hermann, since 7/2022