Soluble and crystalline metabolites as modulators of neutrophil function (A07)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

Soluble and crystalline metabolites have immunomodulatory effects on immune cells that affect various forms of sterile inflammation especially when kidney failure impairs metabolite excretion. The overarching aim of this proposal is to investigate the molecular mechanisms of how soluble and crystalline metabolites (uric acid, oxalate and cholesterol) impact on neutrophil functions including phagocytosis, migration, and NET release, hence yielding insights with potential therapeutic relevance.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Hans-Joachim Anders, since 7/2022; Dr. Stefanie Steiger, since 7/2022