Damage control by somatic mutations of epigenetic regulators in leukocytes after myocardial infarction (B10)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 456687919

This project aims to assess the effect of leukocyte specific somatic mutations in the gene encoding the epigenetic regulator KDM6A on cardiac damage after acute myocardial infarction. Mutations in KDM6A belong to the most prevalent mutations causing clonal hematopoiesis of indeterminate significance (CHIP) in patients with ischemic heart disease. CHIP emerged as a major risk factor for death in patients with cardiovascular pathologies and is relatively common especially in older adults. Addressing the detrimental consequences of such mutations by targeted therapies might improve outcomes of patients with ischemic heart disease.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1531: Damage control by the stroma-vascular compartment
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Privatdozent Dr. Sebastian Cremer