Project Details
Projekt
Vascular phenotype and fibrosis control by phosphatases (A09)
Subject Area
Cardiology, Angiology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 456687919
The project studies phosphatases as critical regulators of damage-induced activation and differentiation events as well as vascular fibrosis. We will use primary human and mouse endothelial cells and fibroblasts as well as reporter cell and mouse lines to identify fibrosis-related interaction partners and substrates of phosphatases of the PTP1B family, focussing on TGFβ1 and chronic oxidative stress. We will also determine how PTP1B controls the nuclear export and stability of transcription factors linked with endothelial-to-mesenchymal transition and systematically check for TGFβ1 regulated phosphatases involved in vascular damage control.
DFG Programme
Collaborative Research Centres
Applicant Institution
Goethe-Universität Frankfurt am Main
Project Head
Professorin Dr. Katrin Schäfer
