Metabolic surveillance of endothelial growth state (A01)

• Subject Area: Public Health, Healthcare Research, Social and Occupational Medicine
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 456687919

Studies from our laboratory have identified the mitochondrial 2-oxoglutarate dehydrogenase (OGDH) complex as a metabolic checkpoint whose activity determines whether endothelial cells (ECs) activate and divide or become quiescent. This function relies on the S(L)-enantiomer of 2-hydroxyglutarate (S-2HG), a metabolite inhibitor of several epigenetic enzymes, whose levels rise when OGDH activity is reduced. This project will study the role of this novel metabolic surveillance mechanism in adjusting endothelial responses during tissue damage, focussing on the interplay between metabolism and epigenetic gene regulation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1531: Damage control by the stroma-vascular compartment
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Michael Potente