Dissecting the role of SND pathway components in ER membrane protein insertion (P16)

• Subject Area: Biochemistry
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450648163

The signal recognition particle independent (SND) pathway targets and inserts a subset of integral membrane proteins into the endoplasmic reticulum membrane, requiring three component proteins: Snd1, Snd2 and Snd3. Using combined structural, biophysical and in vitro reconstitution approaches, we propose to define the precise molecular roles of these proteins and understand how they interact within the SND pathway.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1507: Protein Assemblies and Machineries in Cell Membranes
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Dr. Melanie McDowell