Molecular dynamics simulations of membrane perforation machineries and the nuclear pore complex (P12)

• Subject Area: Biophysics
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450648163

Project P12 uses molecular dynamics simulations to study key steps in the assembly and function of two archetypal membrane pores in eukaryotes: (i) the nuclear pore complex governing the transport between the nucleus and the cytosol, and (ii) the ring-shaped cytolysin-like pores formed by gasdermin in inflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1507: Protein Assemblies and Machineries in Cell Membranes
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Gerhard Hummer