Project Details
Projekt
Structure and dynamics of the TRPV4 ion channel as a cellular signaling hub (P11)
Subject Area
Biochemistry
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 450648163
Project P11 focuses on transient receptor potential vanilloid 4 (TRPV4) as the mediator of multipartite and highly dynamic interactions with lipid and protein partners in the cell. TRPV4 structural dynamics, the interaction of the N-terminus, and its large intrinsically disordered region with the membrane, Pacsin proteins, and the cytoskeleton as well as the molecular consequences of disease mutants will be investigated.
DFG Programme
Collaborative Research Centres
Applicant Institution
Goethe-Universität Frankfurt am Main
Project Head
Professorin Dr. Ute Hellmich
